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Abstract





Sodium valproic acid, a common antiepileptic drug, due to its poor aqueous solubility is absorbed very slowly and erratically after oral administration. So in the work under taken, an attempt was made to enhance its solubility, dissolution rate and thus bioavailability by applying solid dispersion technique followed by formulating it as suspension. Solid dispersions of sodium valproic acid were prepared using hydroxyl propyl methylcellulose, polyvinylpyrrolidone and polyethylene glycol-6000 as carriers and formulated as suspensions. The solid dispersions and suspensions were evaluated for drug content and dissolution rate and particle size. Particle size of suspensions formulated from solid dispersions was significantly reduced compared to conventional suspension. A marked increase in dissolution rate and a good suspend ability was exhibited by sodium valproic acid suspension formulated with solid dispersion than that exhibited by conventional suspension. The SVA: HPMC suspension gave the highest in-vitro drug release profile. Nearly fourfold increase in bioavailability was exhibited by SVA:HPMC suspension when compared with that of conventional suspension. Further suspensions were subjected to stability testing for three months and evaluated for particle size, drug release and sedimentation. Suspensions showed no considerable change with all parameters. Hence it was concluded that solid dispersion system of sodium Valproic acid with a hydrophilic carrier HPMC provided a simple method for preparing a suspension of sodium Valproic acid with increased bioavailability.





Keywords

Bioavailbility, Sodium Valproic acid, HPMC, CMC, PVP, PEG6000.

Article Details

How to Cite
1.
Bhandari Anil, Ranka Khushboo, Rathore KS. Formulation And Evaluation Of A Liquid Oral Dosage Form Of Sodium Valproic Acid For . Int. j. innov. pharm. sci. res. [Internet]. 2022Oct.15 [cited 2022Dec.6];6(10):27-39. Available from: https://ijipsr.com/index.php/IJIPSR/article/view/101