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Abstract
The aim of the work was to improve the dissolution properties of the poorly soluble drug, Efaverinz by the liquisolid compaction technique. The study demonstrated with confidence that the liquisolid technique is promising approach for improvement of solubility of poorly soluble drugs. In vitro drug release of Efaverinz compacts showed increase in dissolution rate of Efaverinz. So PEG 400, PG, Tween 80 could be economic substitute as dissolution enhancing agent. Stability studies showed that there were no significant changes in physical and chemical properties of formulation F5 after 2 months. Propylene glycol in 1:0.25 ratios (F5) was showing best release. F5 was compared with marketed and prepared conventional formulation and result shows better dissolution profile.