Main Article Content
Acetazolamide is a Carbonic Anhydrase Inhibitors drug characterized by low solubility and high permeability which corresponds to BCS class II drug. The purpose of the study was to develop solid dispersion by different methods and investigate them for in vitro and in vivo performance for enhancing dissolution and solubility. The solid dispersion was prepared using PEG 6000, povidone, cross povidone, lactose, Mcc102 as carriers in different ratios by different methods and was characterized for FT-IR. In vitro dissolution studies were performed in 0.1 N HCl and biorelevant media showed enhanced dissolution rate as compared to marketed formulation. The dissolution of prepared formulation (F8) was relatively higher (96%) than marketed formulation. On the basis of the result obtained, it was concluded that solid dispersion is a good approach to enhance solubility of poorly water-soluble Acetazolamide.