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Physalis angulata mainly consists of secosteroids, phenolic compounds, alkaloids, plant steroids and flavonoids. The methanol extract of Physalis angulata was prepared by using Methanol, by maceration method for 72hrs at room temperature against frusemide . The extract was concentrated by simple evaporation at room temperature. A suspension of MEPA in 5% (w/v) Carboxyl Methyl Cellulose (CMC) was prepared for oral administration. As mentioned in table, the diuretic drug like furosemide, and MEPA (250 mg/kg, 500 mg/kg and 1000 mg/kg) of Urine volume were 8.34 ± 0.48, 5.43 ± 0.28, 6.70 ± 0.22 and 7.58 ± 0.62 respectively. Estimation of Na+ (m mol/L) of the diuretic drug like furosemide and MEPA (250 mg/kg, 500 mg/kg and 1000 mg/kg) were 125.62 ± 0.16, 112.46 ± 3.47, 118.24 ± 3.16 and 123.64 ± 3.47 respectively. we can conclude that MEPA treatment produced a marked diuresis when rats were acutely treated. In our study, no lethality was observed at least for the dose and duration used.