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Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy and/or increased health problems. Synephrine is the primary protoalkaloid in Citrus aurantium (bitter orange) and other Citrus species Bitter orange extract and p-synephrine are widely used in weight management and sports performance products. The present reiew has shown that bitter orange peel extract can be used as an alternative to phenyl propanolamine as an anti-obesity agent. The extract from the peel can be formulated into suitable dosage for obese patients. It has been established earlier before this study that synephirine (the main active ingredient in bitter orange peel extract) exerts its adrenergic actions through the stimulation of a different receptor (B2 receptors)


Obesity, Synephirine, Phenyl propanolamine, Bitter orange.

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Shireen Anjum, G.Sukanya, B.Kumari, K.Sameer Hussain. NATURAL BITTER ORANGE PEEL EXTRACT: A REVIEW. Int. j. innov. pharm. sci. res. [Internet]. 2013Apr.2 [cited 2023Jun.1];1(4):398-40. Available from: