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The analgesic efficacy of Diclofenac/Paracetamol given in low doses and Tramadol/Paracetamol has been demonstrated in various painful conditions such as dental pain, sore throat, and dysmenorrheal. Osteoarthritis (OA) is the most common form of joint disease and is an important public health concern. From the present studied we came to know that our results shown marked significant reduction in pain with Tramadol & Paracetamol than with Tramadol & Paracetamol. The efficacy analysis using the WOMAC indicated a significant improvement over 2 weeks in favour of Tramadol & Paracetamol. Use of the WOMAC enabled this study to evaluate improvement not only in pain but also in stiffness and physical function; the results were consistent with the conventional pain assessment scales, with a significantly greater improvement in the mobility of the patients with OA with Tramadol & Paracetamol than with Diclofenac & paracetamol. Decreased the incidence of side effects of Tramadol & paracetamol with reducing analgesic efficacy. It was therefore the most appropriate drug to use for comparison with Tramadol & Paracetamol in an efficacy and safety study of OA pain control.