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Leaves were used in indolent ulcers, gallstones, ophthalmopathy, skin diseases, fever, cough, diarrhoea and abdominal pain, pruritus, cephalalyra, stomatopathy, leprosy, vomiting hiccup, insanity and galactorrhoea. The present study was designed to evaluate the anti-arthritic activity of Aconitum ferox root using complete freund’s adjuvant induced arthritis in albino rats. It was extracted out by the soxhlet apparatus using different solvents including water
and ethanol. The dose of Aconitum ferox was determined by Acute Oral Toxicity following OECD Guidelines. In this various parameters were evaluated including Hind paw volume and edema, Body weight changes, Locomotor activity, Hematological parameters,
Estimation of lipid peroxidation and antioxidant status, Estimation of Superoxide dismutase (SOD) and Radiological assessment. In result, it demonstrated statistically significant level of anti-arthritic effect against freund’s adjuvat induced artthritis in rats. In conclusion, it
suggests identifying and isolating the specific compound needed to produce anti-arthritic effect that can be used in the treatment of Osteoarthritis in future.