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A kidney stone, also known as a renal calculus is a solid concretion or crystal aggregation formed in the kidneys from dietary minerals in the urine. Urolithiasis is a complex process that occurs from series
of several physicochemical event including super-saturation, nucleation, growth, aggregation and retention within the kidneys. Data from in-vitro, in- vivo and clinical trials reveal that phytotherapeutic agents could be useful as either alternative or an adjunct therapy in the management of Urolithiasis. Medicinal plants / natural products are more useful for body because they promote the repair mechanism in natural way. Various plant species of Tribulus terrestris, have been reported to posses antiurolithiatic property. In this study ethenol extracts of Tribulus terrestris Leaves. Linn and standard for dissolving kidney stones- calcium oxalate by an in-vitro model. To check their potential to dissolve experimentally prepared kidney stones- calcium oxalate by an in-vitro model for Tribulus terrestris and cystone as a standard compound collected from market. Ethenoic fraction was more effective in dissolving calcium oxalate (48.5±0.022%). Reference standard-formulation Cystone was found to be more effective (53.5±0.02 %).